Which Toothpaste Is Best for Mouth Ulcers?

If you get mouth ulcers often, the toothpaste question matters more than most people realise: the foaming agent SLS can irritate ulcer-prone mouths, and some studies suggest ulcer sufferers do better on SLS-free formulas. The best toothpaste for an ulcer-prone mouth is gentle, SLS-free, and still contains fluoride. 

So, which toothpaste is best for mouth ulcers? We consulted with dentists and oral health professionals to compile this list of the top five doctor-recommended toothpastes, including our top pick — Enzim Fresh Mint Toothpaste — known for its gentle, healing properties. This guide explains the evidence, what to avoid while an ulcer heals, and the warning signs that need a dentist.

1. Enzim Fresh Mint Toothpaste – Top Recommendation in Singapore

Why it’s great:
Enzim Fresh Mint Toothpaste is SLS-free and powered by natural enzymes such as glucose oxidase and amyloglucosidase, along with proteins like lactoferrin and lysozyme. These support your mouth’s natural defences and help speed up the healing of ulcers. The mild mint flavour provides long-lasting freshness without irritation — ideal for those with sensitive mouths or recurring ulcers.

• Enzyme-based formula heals and protects

• Soothes soft tissue and sensitive gums

• SLS-free and non-irritating

• Halal-certified and suitable for daily use

2. Sensodyne Repair & Protect

Why it’s great:
Designed for those with sensitive teeth, Sensodyne Repair & Protect uses NovaMin technology to build a protective layer over exposed dentine, reducing pain from triggers like heat, cold, and acidity. While it isn’t specifically formulated for ulcers, its low-abrasion formula and lack of harsh chemicals make it a suitable choice for people prone to mouth sensitivity.

• Strengthens enamel and reduces sensitivity

• Low-abrasion and gentle on oral tissues

• Recommended by dentists for long-term use

3. Biotène Dry Mouth Toothpaste

Why it’s great:
Dry mouth is one of the common causes of mouth ulcers, especially among older adults or individuals on long-term medication. Biotène is specially developed to provide soothing moisture, using enzymes and a pH-balanced formula to support natural healing. It’s SLS-free and suitable for daily use.

• Helps relieve dry mouth and irritation

• Moisturises soft tissues to reduce ulcer risk

• Free from alcohol and harsh detergents

4. Oral7 Moisturising Toothpaste

Why it’s great:
Oral7 contains natural salivary enzymes to promote oral healing and prevent infection. Like Enzim, it supports the mouth’s natural immune function and is free of SLS, making it a great option for individuals who suffer from ulcers due to dryness or chemical sensitivity.

• Contains natural enzymes for healing

• Hydrates and soothes the mouth

• SLS-free and safe for long-term use

5. Zendium Toothpaste

Why it’s great:
Zendium boosts the natural protective power of your mouth by using mild ingredients and natural proteins. It’s clinically proven to be gentle on soft tissue and helps maintain a balanced oral microbiome. Ideal for those who prefer a holistic approach to oral health.

• Mild formula with no SLS or foaming agents

• Strengthens mouth’s natural defences

• Great for people with frequent ulcers and irritation

Final Thoughts: Which Toothpaste Is Best for Mouth Ulcers?

When determining which toothpaste is best for mouth ulcers, it’s important to choose one that’s free from irritants like SLS and rich in healing or soothing ingredients. For the Singapore market, Enzim Fresh Mint Toothpaste stands out with its enzyme-based, non-irritating formula that supports healing and maintains oral comfort, making it our top recommendation.